A Fatal Case of Nosocomial Legionnaires' Disease: Implications From an Extensive Environmental Investigation and Isolation of the Bacterium From Blood Culture.

colonized with CPE. Prospective studies using innovative laboratory techniques are needed on patients with CPE during outbreaks and in endemic settings over periods of time, while in the hospital and after discharge. These studies will help us further understand the natural history of CPE colonization and determine the host/patient, environmental, and microbial factors that may help us predict which patients remain transiently, intermittently, or permanently colonized. This work is required to scientifically inform infection prevention and control strategies on the use of contact precautions and to facilitate risk stratification of patients previously identified as CPE colonized. This research becomes increasingly important as the number of patients with CPE increases, especially in settings where single room/isolation facilities are limited.